Stuff You Should Know, often abbreviated as SYSK, is a podcast and video series published by iHeartRadio and hosted by Josh Clark and Charles W. "Chuck" Bryant. The podcast, which releases episodes several times a week, educates listeners on a wide variety of topics, often using popular culture as a reference, giving the podcast comedic value.

Since debuting in 2008, the podcast is consistently ranked in the Top 10 on iTunes and is one of the most popular podcasts in the world, being downloaded millions of times each month. On October 3, 2018, the podcast started releasing additional short episodes titled Short Stuff, where they cover topics that don't warrant the length of a full episode. A number of other types of media, including a TV show and books, have been spun off by the podcast.