In a post-apocalyptic future humans live in peace with androids in a domed city. However, a strange series of murders has intruded into bored inspector Re-l Mayer's life.

Yuji Kaido was diagnosed with a serious disease and since there was no cure for the unknown illness, he was cryogenically frozen. Twenty years later, he wakes up to see the Earth like it has never been before-the humanity is almost eradicated, because of the alien bugs called the Blue. However, the humanity still lives, a few selected humans have retreated to the space station called Second Earth. Yuji is taken back to the Second Earth, where he finds out that there are people that have been also cryogenically frozen and now they will be used as a force to combat the Blue.

Gungrave follows the story of best friends Brandon Heat and Harry MacDowell as they join and rise in the ranks of Big Daddy's Millenion crime syndicate. The story begins in the future revealing Brandon Heat has become a creature now known as Beyond The Grave killing monsters with two very large guns and wicked looking machine gun on his back and that Harry MacDowell is now the Boss of Mellinion and has become a cruel leader who has earned himself the nickname Bloody Harry. The story strafes between the past and the future to reveal why Brandon has become a non-talking monster killer and the series of events that caused Harry to become so evil.

Seemingly unconnected citizens of Tokyo are targeted for bludgeoning by a boy with a golden baseball bat. As detectives try to link the victims, they discover that following the assaults, the victims' lives have improved in some way.

In a post-apocalyptic future where humans live in domed cities surrounded by wasteland, wolves are assumed to be two hundred years extinct. Yet wolves do walk among them, disguising themselves as humans in order to survive in the human world. Now four young wolves will follow the scent of Lunar Flowers on a dangerous quest to find that which legend promises them: Paradise.

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