Told from the perspective of an unseen documentary filmmaker, the series offers an honest, often-hilarious perspective of family life. Parents Phil and Claire yearn for an honest, open relationship with their three kids, but a daughter who is trying to grow up too fast, another who is too smart for her own good, and a rambunctious young son make it challenging. Claire's dad Jay and his Latina wife Gloria are raising two sons together, but people sometimes believe Jay to be Gloria's father. Jay's gay son Mitchell and his partner Cameron have adopted a little Asian girl, completing one big -- straight, gay, multicultural, traditional -- happy family.

Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

Ross Geller, Rachel Green, Monica Geller, Joey Tribbiani, Chandler Bing, and Phoebe Buffay are six twenty-somethings living in New York City. Over the course of 10 years and seasons, these friends go through life lessons, family, love, drama, friendship, and comedy.

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